I can't figure out what causes it, but the S49 screens and keyboard light guides will get 'stuck' on a specific patch. What I really like using it for is to browse Komplete Kontrol on the keyboard and change patches, settings, etc. I recently added a NI Komplete Kontrol S49 MK2 to my setup (complete setup notes at the end), and while I love it, the behavior is a bit weird. Hey all, really could use some advice here. Also filed a support ticket with Native Instruments.) (I've also posted this on Native Instrument's and Ableton's forums, but curious if anyone here has experienced something similar. The versions I'm using are Komplete Kontrol 2.8.0 and Maschine 2.16. I updated and then tried to replicate this using Live in native M1 mode and the native M1 Komplete Kontrol VST3 plug-in, and it all seems fixed.

And then Native Instruments released the M1 native version of Komplete Kontrol on October 31. I addressed this by only using Live in Rosetta (emulated) mode and then also using the VST3 version of Komplete Kontrol. In short, I was using Live in native M1 mode but still loading the AU version of Komplete Kontrol, which had some understandably wrong behavior.

S49 mk2